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采用化学气相沉积法在硬质合金基体上沉积具有不同织构择优的α-Al2O3涂层,通过扫描电子显微镜(SEM)、X射线衍射(XRD)分别对其微观组织和机械性能进行分析。研究结果表明,通过改善过渡层的氧化气氛,氧化铝的过渡层结构为针状物,成功制备不同织构的氧化铝涂层,涂层结合力良好。 相似文献
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Kamran Zaheer 《Drug development and industrial pharmacy》2018,44(3):444-451
Food induced viscosity can delay disintegration and subsequent release of API from solid dosage form which may lead to severe reduction in the bioavailability of BCS type III compounds. Formulations of such tablets need to be optimized in view of this postprandial viscosity factor. In this study, three super disintegrants, croscarmellose sodium (CCS), cross-linked polyvinylpolypyrrolidone (CPD), and sodium starch glycolate (SSG) were assessed for their efficiency under simulated fed state. Tablets containing these disintegrants were compressed at 10 and 30?KN, while taking lactose as a soluble filler. In addition to other compendial tests, disintegration force of these formulations was measured by texture analysis. Comparison of parameters derived from force – time curves revealed a direct relation of maximum disintegration force (Fmax) and disintegration force development rate (DFDR) with compressional force in fasted state, whereas an inverse relationship of Fmax and DFDR with compressional force was observed in fed state. The gelling tendency of disintegrants influenced the rate of release of API in simulated fed and fasted states when compressional force was changed. These observations recommend the evaluation of formulations in simulated fed state, in the development stage, with an objective of minimizing the negative impact of food induced viscosity on disintegration. Use of disintegrants that act without gelling or can counteract the effect of gelling is recommended for tablet formulations with reduced disintegration time (DT) and mean dissolution time (MDT) in fed state, respectively. 相似文献
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Hamid Azizi Bondarabady 《Journal of Urbanism》2018,11(2):202-232
According to many researchers and scholars, religious beliefs can be considered as the most influential factor in forming Muslim urban spaces and their architectural elements. In fact, historical cities reflect the culture and beliefs of their residences. Among all historical places in Iranian cities, the historical texture of the city of Yazd, especially the quarters since the age of Qajar dynasty, are well preserved. The present study aims at identifying the Islamic principles and values influencing the formation of architectural spaces and the extent of their applications in one of the historical quarters known as Golchinan. The results of the conformation of the theoretical findings with the data acquired from field studies revealed that almost 90% of the urban and architectural spaces (e.g. residential areas, mosques, bazaars, and pathways) in Yazd are directly influenced by Islamic principles. In other words, there is a strong conformity between the accepted Islamic values of the society and what actually was applied to urban constructions during Qajar dynasty. 相似文献
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Jagoda O. Szafrańska Bartosz G. Sołowiej 《International Journal of Food Science & Technology》2020,55(5):1971-1979
The objective of this study was the evaluation of different fibres (bamboo, acacia, potato or citrus) addition on texture, rheological and sensory properties of acid casein processed cheese sauces. Fibres used in production of sauces had an impact on the texture, viscosity, viscoelastic and sensory properties. The largest increase in viscosity was observed in products with addition of potato fibre, which have good water holding and adsorption capacity. Processed cheese sauce with the addition of citrus fibre was characterised by the highest values in general, and the increase of this feature in the tested samples was regular. Adhesiveness was the highest in products with 1% addition of every fibre. The lowest values of viscosity single shear, G′ and G″ moduli, among all tested, had sauces with acacia fibre. Moreover, they had the most thin liquid consistency, which was different from preferred one. 相似文献
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Objective and quantitative assessment of skin conditions is essential for cosmeceutical studies and research on skin aging and skin regeneration. Various handcraft-based image processing methods have been proposed to evaluate skin conditions objectively, but they have unavoidable disadvantages when used to analyze skin features accurately. This study proposes a hybrid segmentation scheme consisting of Deeplab v3+ with an Inception-ResNet-v2 backbone, LightGBM, and morphological processing (MP) to overcome the shortcomings of handcraft-based approaches. First, we apply Deeplab v3+ with an Inception-ResNet-v2 backbone for pixel segmentation of skin wrinkles and cells. Then, LightGBM and MP are used to enhance the pixel segmentation quality. Finally, we determine several skin features based on the results of wrinkle and cell segmentation. Our proposed segmentation scheme achieved a mean accuracy of 0.854, mean of intersection over union of 0.749, and mean boundary F1 score of 0.852, which achieved 1.1%, 6.7%, and 14.8% improvement over the panoptic-based semantic segmentation method, respectively. 相似文献